What refers to a popular video meme clip that originated from a Youtube video titled “Anti Drug Games” uploaded by American Youtuber and Internet personality Jonathan Aryan Jafari A.K.A. JonTron on September 25, 2014.
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JonTron is known for reviews and parodies of video games, movies and other media on his Youtube channel.
The WHAT meme is often used in reaction videos and video memes.